Eukaryotic initiation factor 3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation. [2] It is essential for most forms of cap-dependent and cap-independent translation initiation.

The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal ...

Jan 2, 2018 · The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling.

eIF3 independently binds the 40S ribosomal subunit, multiple initiation factors, and cellular and viral mRNA. [7] In mammals, eIF3 is the largest initiation factor, made up of 13 subunits (a-m).

Sep 7, 2015 · The eukaryotic initiation factor 3 (eIF3) is a thirteen-subunit accessory factor within the ribosomal 43S complex involved in binding of mRNAs and scanning to find the initiation codon.

Here, we unite recent structural views of the eIF3–40S complex and discus all known eIF3 roles to provide a broad picture of the eIF3’s impact on translational control in eukaryotic cells.

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state.

Oct 1, 2006 · eIF3 functions in specialized reinitiation events that are involved in gene-specific translational control. As noted earlier, it seems that eIF3 has functions in scanning and AUG recognition that are essential for reinitiation during translation of GCN4.

Apr 9, 2025 · Here, we show that translational regulation by EIF3 subunit D (EIF3D) is critical for maintaining the identity of human primed PSCs. Loss of EIF3D resulted in impaired self-renewal of primed PSCs and their differentiation potential into three germ layer lineages. As a mechanism to explain these phenotypes, we revealed that EIF3D regulates the ...

Mar 28, 2025 · EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A) is a Protein Coding gene. Diseases associated with EIF3A include Craniotubular Dysplasia, Ikegawa Type and Breast Cancer. Among its related pathways are Peptide chain elongation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.