ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). [5] It is …

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its …

Nov 30, 2023 · ZAP-70 deficiency is a rare combined immunodeficiency (CID) with an autosomal recessive pattern of inheritance. The disease was first described in 1989 in a patient of …

The tyrosine ZAP-70 (zeta-associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal transduction pathways in T cells following T-cell receptor (TCR) …

ZAP-70 (zeta-associated protein 70) deficiency is an immunodeficiency disorder involving impaired T-cell activation caused by a signaling defect. Diagnosis is by detecting lymphopenia, …

The ZAP70 gene provides instructions for making a protein called zeta-chain-associated protein kinase. This protein is part of a signaling pathway that directs the development of and turns on …

ZAP-70 is required for intracellular calcium ion mobilization in response to SDF-1alpha/CXCL12-induced prolonged activation of extracellular signal-related protein kinase in Jurkat T …

Apr 26, 2018 · In this article, we describe recent structure-based insights into the regulation and substrate specificity of ZAP-70, and then we review novel methods for determining the role of …

Oct 1, 2019 · What is ZAP-70 (70-kDa zeta-associated protein), and what can it reveal about a CLL patient’s prognosis? Experts Drs. Nitin Jain, Alessandra Ferrajoli and Javier Munoz …

In this article, we describe recent structure-based insights into the regulation and substrate specificity of ZAP-70, and then we review novel methods for determining the role of ZAP-70 …