Objectives: Aging exacerbates liver neutrophil infiltration and alcohol-associated liver disease (ALD) in mice and humans, but the underlying mechanisms remain obscure.

SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting. This hepatocyte-derived endocrine signaling appears to regulate expression of genes that control a brown fat-like program in white adipose tissue, energy expenditure, and adiposity.

Dr. Yu Li obtained his PhD degree from the Department of Molecular and Cellular Biology at University of Guelph, Ontario, Canada in 2008. Then he did his postdoctoral training at Whitaker Cardiovascular Institute, Boston University Medical School, MA, USA.

We report that liver metastases diminish immunotherapy efficacy systemically in patients and preclinical models. Patients with liver metastases derive limited benefit from immunotherapy independent of other established biomarkers of response.

The liver is one of the major metabolic organs, and is essential for the regulation of whole-body glucose and lipid homeostasis. Impairment of liver function is an early hallmark of obesity-associated metabolic disorders, such as insulin resistance and type 2 diabetes.

Yu LI, Professor (Associate) | Cited by 1,023 | of Xi'an Jiaotong University, Xi’an (XJTU) | Read 44 publications | Contact Yu LI

Jul 1, 2023 · Human exposure to Pb 2+ can cause dysfunction in the central nervous, hematopoietic system, liver, kidney, etc. (Alisha and Gupta, 2018). It is necessary to concern about the toxicity of nanoplastics enriched with Pb 2+, which probably results in unforeseen physiological effects on human beings by drinking water.

Yu Li's 17 research works with 149 citations and 557 reads, including: A bifunctional hepatocyte-mitochondrion targeting nanosystem for effective astaxanthin delivery to the liver

Jan 4, 2021 · We demonstrate that liver-directed radiotherapy reshapes the liver immune microenvironment, stops hepatic siphoning of T cells and restores immunotherapy efficacy in models of liver metastases....