Mar 30, 2025 · YES1 (YES Proto-Oncogene 1, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with YES1 include Sarcoma and Colorectal Cancer. Among its …

Tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene. [5] [6] This gene is the cellular homolog of the Yamaguchi sarcoma virus …

Sep 6, 2022 · YES1 is a nonreceptor tyrosine kinase that belongs to the SRC family of kinases (SFK) and controls multiple cancer signaling pathways. YES1 is amplified and overexpressed …

Oct 17, 2023 · Amplification of YES1 or increased expression/activity of YES has recently emerged as a mechanism of acquired resistance to targeted therapies and chemotherapeutic …

Nov 15, 2019 · We proved the oncogenic activity of YES1, displayed the YES1 gene amplification in clinical, generated an inhibitor that was highly selective against SFK and especially against …

YES1 plays a pivotal role in promoting cell proliferation, survival, and invasiveness during tumor development. Recent findings indicate that YES1 expression and activation are associated …

YES1 genetic depletion by CRISPR/Cas9 technology significantly reduced tumor growth and metastasis. YES1 plays an important role in the emergence of resistance to HER2-targeted …

Feb 4, 2024 · YES1 is essential for NSCLC carcinogenesis. YES1 overexpression induced metastatic spread in preclinical in vivo models. YES1 genetic depletion by CRISPR/Cas9 …

Oct 1, 2019 · Measurements and Main Results: We demonstrated that YES1 is essential for NSCLC carcinogenesis. Furthermore, YES1 overexpression induced metastatic spread in …

We report response to SRC family kinase (SFK) inhibition in a patient whose lung cancer exhibited YES1 amplification, without any well-established primary driver alteration, suggesting …