Welcome to the Hashem Lab Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their ...

[email protected] LinkedIn Researchgate Google scholar Orcid. Stéphanie Durrieu-Gaillard. More. Stéphanie Durrieu-Gaillard. Research Assistant. [email protected] ResearchGate Orcid. José Eduardo Gomes. More. José Eduardo Gomes. Maître de Conférences (Assistant Prof.)

[email protected]. ... Institut de Européen de Chimie et Biologie (IECB) ARNA-U1212, EQ Hashem 2 Rue Rober Escarpit 33600 Pessac France Developed by ...

Oct 21, 2024 · Hashem Y, Des Georges A, Dhote V, Langlois R, Liao YH, Grassucci RA, Hellen CUT, Pestova TV, Frank J (2013). Cell 153:1108-1119. High-resolution cryo-EM structure of the Trypanosoma brucei eukaryotic ribosome

Sp ecies-specific aspects in eukaryotic mRNA translation modulation and their implications in diseases – ERC Consolidator Grant SPICTRANS (grant number: 101088541) (2023-2028)

Mitochondria usually possess their own genome and translation apparatus. Kinetoplastids for instance, such as trypanosomes, count a single mitochondrion where the mitochondrial DNA is called the kinetoplast (k-DNA) and consists of concatenated circular DNA molecules, made of maxicircles and minicircles.

Hashem Lab Marie Sissler Publications and PhD direction. 1. Sissler, M., Giegé, R. & Florentz, C. (1996) Arginine aminoacylation identity is context-dependent and ensured by alternate recognition sets in the anticodon loop of accepting tRNA transcripts. EMBO J., 15, 5069-5076. 2.

THE HASHEM LAB. Home; Members; Research; Publications; Funding; Events&Pics; Contact; mRNA translation in mammals. Home / mRNA translation in mammals. Protein synthesis is the essential process required for growth and development in all living organisms. It relies on the translation of the messenger RNA (mRNA) into amino acids that fold and ...