Jul 2, 2024 · We identified three prominent NK cell subsets in healthy human blood: NK1, NK2 and NK3, further differentiated into six distinct subgroups. Our findings delineate the molecular characteristics,...

Dec 5, 2019 · In particular, NK cells from 3 clusters expressed high levels of XCL1 and XCL2, which encode 2 chemokines known to recruit XCR1+ cross-presenting DCs into tumors. In contrast, NK cells from 2 other clusters showed a higher level of expression of cytotoxicity genes.

XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation.

Feb 22, 2018 · In NK cell-depleted mice, Ptgs1/Ptgs2 −/− BRAF V600E tumors expressing XCL1 grew more slowly than mock-transduced cells (Figure 5F), suggesting that XCL1-mediated recruitment of cDC1 can partially compensate for the loss …

XCL1 is secreted by NK cells and by antigen-specific CD8 + T-cells, along with other chemokines including IFN-gamma. [12] This process likely facilitates the cross-presentation of antigens by the dendritic cells.

Our findings reveal a cellular and molecular checkpoint for intratumoral cDC1 recruitment that is targeted by tumor-derived PGE2 for immune evasion and that could be exploited for cancer therapy.

Feb 10, 2012 · Secretion of the chemokine XCL1 by activated NK cells specifically attracts XCR1-expressing DCs capable of antigen cross-presentation. This ensures an effective communication between these cells in the innate phase of the immune response.

Feb 19, 2021 · XCR1 mediates chemotaxis of cDC1s towards CD8 + T cells and NK cells, because they are the main producers of the ligand of XCR1, XC chemokine ligand 1 (XCL1), the ligand of XCR1 (12, 23). Besides exclusive expression of XCR1, cDC1s have a higher expression of the TLR-3 compared to other DCs subsets.

Feb 16, 2018 · A recent study from Caetano Reis e Sousa and colleagues now shows that natural killer (NK) cells recruit cDC1s to the tumour microenvironment by producing the chemokines CCL5 and XCL1.

Mar 1, 2012 · The C class chemokine XCL1 is expressed by activated T cells, NK cells, and NKT cells, particularly during Th1-type immune response. The XCL1 receptor XCR1 is exclusively expressed by the DC subpopulation that is potent in antigen presentation to T cells and facilitates cytotoxic T cell response.