Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the C chemokine family that is also known as lymphotactin. Chemokines are known for their function in inflammatory and immunological responses.

Mar 30, 2025 · XCL1 (X-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with XCL1 include Sodoku Disease and Immune Deficiency Disease. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation.

The chemokine XC motif chemokine ligand 1 (XCL1) is an unusually specialized member of a conserved family of around 50 small, secreted proteins that are best known for their ability to stimulate the directional migration of cells. All chemokines ...

Mar 1, 2012 · XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1–XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response.

XCL1 displays antimicrobial activity against E. coli and S. aureus. XCL1-mediated inhibition is associated with direct interaction of the chemokine with the HIV-1 envelope. In native annulus fibrosus tissue homeostasis and repair, CXCR3 is evident, whereas XCL1 could not be detected.

Oct 10, 2008 · In this study, we aim to explore the role of XCL1, a chemokine associated with immune suppression and allergy, on CD4 + CD25 high CD127 low/− regulatory T cell (Treg) function in AA. Flow cytometry and PCR analysis showed a reduction in XCL1 and XCR1 expression in AA Treg compared with healthy control and nonallergic asthmatic counterparts.

Nov 23, 2023 · Title: The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation. Diepoxybutane induces the expression of a novel p53-target gene XCL1 that mediates apoptosis in exposed human lymphoblasts.

Mar 2, 2020 · Through immunohistochemistry analysis, we identified XCL1 expression on tumor cells in 13/24 (54%) of MCT-SCCs but not in MCTs. XCL1 expression was also significantly associated with the number...

Treatment with CEA-specific, XCL1-secreting CAR-T cells for CEA-positive tumors promoted the generation of CD8 + T cells against tumor neoantigens, mediating a long-term antitumor immunity against heterogeneous CRCs.