Oct 1, 2004 · Here, we report that mammalian Ryk, unlike the Drosophila Ryk homolog Derailed, functions as a coreceptor along with Frizzled for Wnt ligands. Ryk also binds to Dishevelled, …

Dec 10, 2009 · Conserved Ryk transmembrane proteins, tyrosine kinase-related Wnt receptors, are important during neurogenesis, axon guidance and synaptogenesis. Here, we review the …

Jun 7, 2022 · Our data indicate that RYK signaling through β-catenin and Nuclear Factor kappa B (NF-κB) is part of a safeguard mechanism against mesenchymal cell death, excessive …

We here investigate the role of the non-canonical Wnt receptor Ryk in hematopoiesis and lymphoid development. We show that there are dynamic changes in Ryk expression during …

Ryk is a transmembrane receptor tyrosine kinase (RTK). It functions as a receptor of Wnt proteins required for cell-fate determination, axon guidance, and neurite outgrowth in different …

Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan receptors because their ligands were unknown. They are now known to contain functional extracellular …

Jan 1, 2006 · The versatility and complexity of Wnt signaling has been further highlighted by the emergence of a novel family of Wnt receptors, the Ryk family. In mammals and flies, Ryk is a …

Sep 9, 2019 · Non-canonical Wnt signaling through the Ryk receptor establishes regional subdomains within the MGE along the rostral-caudal axis. These subdomains are defined by …

Nov 11, 2008 · Ryk protein is a receptor for Wnt proteins. Our discovery has revealed an unexpected mechanism of Wnt signaling in which Ryk undergoes specific proteolytic cleavage …

Understanding how extracellular Wnt ligands interact with transmembrane receptors to activate intracellular signaling cascades is of broad importance to biology and to human disease …