The main inhibitory effects of p53 on Wnt signaling include GSK3β and SIAH1-dependent ubiquitination of β-catenin, miRNA and lncRNA-mediated repression of Wnt target genes, and induction of secreted Wnt antagonists such as DKK1 (B). p53 stimulates Wnt signaling by increasing the expression of different WNT ligands and Fzd receptors (C).

Mar 15, 2022 · Over recent decades, a high level of interaction between the two pathways has been revealed. Here, we provide a comprehensive overview of molecular interactions between the p53 and Wnt pathway discovered in cancer, including complex feedback loops …

May 21, 2021 · Our study advanced understanding in two fundamental subjects: (1) identification of p53 as a key node negatively involved in Wnt/ß-catenin-mediated osteogenesis; (2) revealing of a...

Jul 31, 2019 · Loss of p53 in mouse models of breast cancer leads to activation of WNT signalling, which promotes metastatic spread by inducing systemic neutrophilic inflammation.

Pharmacological and genetic blockade of WNT secretion in p53-null cancer cells reverses macrophage production of IL-1β and subsequent neutrophilic inflammation, resulting in reduced metastasis formation.

Jan 5, 2017 · In this study, we outline a regulatory network that involves the p53 tumor suppressor family and the Wnt pathway acting together with the TGF-β pathway in mesendodermal differentiation of mouse and human embryonic stem cells.

Approximately half of all cancers have p53 inactivating mutations, in addition to which most malignancies inactivate the p53 pathway by increasing p53 inhibitors, decreasing p53 activators, or inactivating p53 downstream targets. ... p53 gene deletion increases neutrophil levels through uncontrolled WNT signaling, leading to metastasis . (7 ...

Our results indicate that mut-p53 GOF acts as a positive regulator of canonical Wnt signaling and participates in the induction of resistance to 5-FU in colon cancer cells. Keywords: p53, Canonical Wnt signaling, Mutant p53 gain-of-function, β-Catenin phosphorylation, 5-FU chemoresistance.

Jun 19, 2020 · Recent genomic clustering analyses revealed that p53/Rb and Wnt/β-catenin are the leading pathways altered in the ACC molecular subgroup with the poorest outcome [9, 10, 11], suggesting that...

Jan 3, 2025 · To investigate a possible mechanism for Wnt signaling activation in cancer cells in which the mutant p53 protein is destabilized and undetectable, we used AKTP Null as a model for these p53-destabilized cells in the p53-mutant tumors.