This study proposed a multistep and multi-kinase model for DVL activation in the Wnt/β-catenin pathway which subsequently induces a de-activation mechanism driven by CK1δ/ε-mediated …

Wnt signaling controls a variety of developmental and homeostatic events. As a key component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors to downstream …

Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh (Dvl in mammals) is a cytoplasmic phosphoprotein that acts directly …

Dishevelled (DVL) proteins precisely control Wnt signaling pathways with many effectors. While substantial research has advanced our understanding of DVL’s role in Wnt pathways, key …

Wnt induces Dvl, via the DIX domain, to bind to and activate PIP5K, and the resulting PIP 2 production is suggested to promote LRP6 clustering and phosphorylation, although the …

Jan 3, 2022 · In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and …

Jul 14, 2020 · Dvl (Dishevelled) is one of several essential nonenzymatic components of the Wnt signaling pathway. In most current models, Dvl forms complexes with Wnt ligand receptors, …

May 1, 2010 · Dvl polymerization promotes the clustering of Wnt-LRP6/5-Fz to form signalosomes, resulting LRP6 phosphorylation by GSK3, CK1γ and other CK1. The binding of …

Aug 23, 2021 · Dishevelled (Dvl) is a key player of Wnt signaling pathways with the ability to integrate and relay complex Wnt signals in normal and aberrant cellular contexts.

Apr 4, 2023 · To understand how WNT binding to FZD stimulates intracellular signaling and influences downstream pathway selectivity, we investigated the dynamic changes in the FZD 5 …