Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene. [5] The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have are critical in tissue homeostasis, embryonic development, and disease.

Sep 14, 2015 · Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type.

Jan 3, 2022 · Extracellular signals are mainly mediated by Wnt proteins, including Wnt3a, Wnt1, and Wnt5a. The cell membrane segment mainly contains the Wnt receptors Frizzled (specific sevenfold...

Mar 30, 2025 · WNT3A (Wnt Family Member 3A) is a Protein Coding gene. Diseases associated with WNT3A include Hypophosphatasia, Adult and Short Stature And Advanced Bone Age With Or Without Early-Onset Osteoarthritis And/Or Osteochondritis Dissecans .

Jun 24, 2019 · Wnt3a is an attractive candidate target for therapeutic intervention in the pathogenesis of cancer. In this review, we summarized roles of the Wnt3a ligand in the pathogenesis of different cancers including colorectal, prostate, hepatocellular carcinoma, lung cancer and leukemia.

Cytoskeletal reorganization by soluble Wnt-3a protein signalling. Genes Cells 3: 659–670 [Google Scholar] Silhankova M, Port F, Harterink M, Basler K, Korswagen HC 2010. Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.

Feb 8, 2025 · Wnt-3a increases neurogenesis during the differentiation of ReNcell VM cells. Neurogenesis induced by Wnt-3a is independent of the transcriptional activity of Wnt/beta-catenin pathway in ReNcell VM cells.

Jan 14, 2025 · Wnt-3a increases cell proliferation and differentiation of neural progenitor cells from postnatal and adult mice brain. Results suggest that Wnt-3a inhibits chondrogenesis by stabilizing cell-cell adhesion and that it causes dedifferentiation of chondrocytes by activation of beta-catenin-Tcf/Lef transcriptional complex and the c-Jun/AP-1 pathway.

We found that purified, recombinant WNT-3A efficiently induces WNT/β-catenin signaling in ΔG7 cells in both the absence and presence of G i/o-blocking PTX. Furthermore, cells completely devoid of G protein expression, so called Gα-depleted HEK293 cells, maintain responsiveness to WNT-3A with regard to the hallmarks of WNT/β-catenin signaling.

Wnt3a, an important member of the Wnt family, activates the canonical Wnt signaling pathway to exhibit its biological functions. It is mainly involved in embryonic development, neural development, cell differentiation, proliferation, and tumorigenesis.