Jun 2, 2023 · Our findings reveal systemic efficacy of a bioengineered FZD 4 -selective WNT surrogate during ischemic BBB dysfunction, with potential applicability to adult CNS disorders characterized by an...

Wnt/β-catenin signaling is important for blood-brain barrier (BBB) development and is implicated in BBB breakdown under various pathophysiological conditions. In the present study, a comprehensive characterization of the relevant genes, transport ...

Feb 18, 2022 · However, safe therapeutic use of Wnt ligands is complicated by their pleiotropic Frizzled signaling activities. Taking advantage of the Wnt7a/b-specific Gpr124/Reck co-receptor complex, we genetically engineered Wnt7a ligands into BBB-specific Wnt activators.

Mar 10, 2022 · Now, a study in Science reports the development of Wnt analogues that can repair the BBB in animal models of various neurological disorders. The BBB comprises a dynamic barrier of CNS...

Dec 19, 2022 · In the cerebral microvessels of APP/PS1 mice and amyloid-β-treated brain endothelial cells, we found suppressed Wnt/β-catenin signalling triggered by an increase of GSK3β activation, but not an inhibition of the AKT pathway or switching to the Wnt/planar cell polarity pathway.

Feb 18, 2022 · In a "hit-and-run" adeno-associated virus-assisted CNS gene delivery setting, these new Gpr124/Reck-specific agonists protected BBB function, thereby mitigating glioblastoma expansion and ischemic stroke infarction.

Nov 10, 2021 · Endothelial cells (ECs) in the central nervous system (CNS) acquire their specialized blood–brain barrier (BBB) properties in response to extrinsic signals, with Wnt/β-catenin signaling coordinating multiple aspects of this process.

Our data demonstrates that Wnt/β-catenin signaling is essential for CNS angiogenesis and the expression of BBB-specific transport molecules. This provides evidence that angiogenesis and BBB formation are at least in part linked.

Jul 5, 2022 · Targeting LRP6 in the Wnt/β-catenin pathway in BECs alleviates BBB dysfunction. In the Alzheimer’s disease (AD) brain, Aβ oligomers suppress Wnt/β-catenin signalling in the BECs, leading to reduced expression of endothelial functional proteins and BBB malfunction.

Dec 23, 2019 · Wnt/β-catenin signaling is important for blood-brain barrier (BBB) development and is implicated in BBB breakdown under various pathophysiological conditions.