Jan 2, 2020 · Here we show that the forces exerted at the ventral side of adherent cells during reovirus uptake exceed the binding strength of biotin-neutravidin anchoring viruses to a biofunctionalized...

The uptake of a virus into a cell involves as a first step the adsorption of particles and as a second step the penetration in which virus nucleic acid or nucleoprotein is transferred to the cytoplasmic side of the plasma membrane.

In this review, we focus on host glucose, glutamine, and fatty acid metabolism and highlight the pathways manipulated by the different classes of viruses to increase their replication. We also explore a new system of viral hormones in which viruses mimic host hormones to manipulate the host endocrine system.

It has recently been shown that SARS-CoV-2 enters cells via receptor-mediated endocytosis, as expected from previous studies of other coronaviruses. 1 ACE2 is the receptor for SARS-CoV-2, which unlocks access to the endocytic uptake of the virus. 2 It has also been demonstrated that a two-pore channel (TPC2) is critically important for SARS-CoV ...

6 days ago · Human and avian influenza A viruses bind to sialic acid (Sia) receptors on cells as their primary receptors, and this results in endocytic uptake of the virus. While the role of Sia on glycoproteins and/or glycolipids for virus entry is crucial, …

Apr 13, 2021 · In this study, we provide evidence that M1 AMs strongly take up, amplify, and release SARS-CoV-2, thus spreading the viral infection, while M2 AMs conversely degrade the virus and limit its...

Dec 2, 2024 · Viruses have evolved strategies to breach host cell defenses, initiating infection and hijacking cellular machinery. The entry process begins with the virus identifying susceptible cells, determined by specific receptors on the cell surface.

Feb 26, 2019 · The cellular uptake of nanoparticles or viruses requires that the gain of adhesion energy overcomes the cost of plasma membrane bending. It is well known that this leads to a minimal particle size for uptake.

Viral entry is the earliest stage of infection in the viral life cycle, as the virus comes into contact with the host cell and introduces viral material into the cell. The major steps involved in viral entry are shown below. [1] . Despite the variation among viruses, there are several shared generalities concerning viral entry. [2]

Sep 16, 2010 · Our data indicated that the primary mechanism of ZEBOV uptake is a macropinocytosis-like process that delivers the virus to early endosomes and subsequently to late endosomes. These findings aid in our understanding of how filoviruses infect cells and suggest that disruption of macropinocytosis may be useful in treatment of infection.