Viral infectivity factor, or Vif, is an accessory protein found in HIV and other lentiviruses. Its role is to disrupt the antiviral activity of the human enzyme APOBEC (specifically APOBEC3G, "A3G" in short, and other A3 enzymes) by targeting it for ubiquitination and cellular degradation.

The viral infectivity factor (Vif) of HIV type-1 (HIV-1) is essential for efficient viral replication, yet was, until recently, enigmatic. This resulted from the complexity and cellular specificity of its function and the correspondingly complex systems that are required for its investigation.

HIV-1 virion infectivity factor (Vif) was identified as an accessory gene right after the HIV-1 genome was sequenced. It is well conserved among lentiviruses except in equine infectious virus and plays a crucial role in the viral life cycle to facilitate viral infectivity as its name indicates ( Desrosiers et al., 1998 ).

Jul 7, 2023 · HIV-1 hijacks a host ubiquitin ligase complex using a viral infectivity factor, Vif, to degrade the antiviral factor, APOBEC3G (A3G) 1, 2, 3, 4, 5. A3G is a human, single-stranded DNA (ssDNA)...

These data demonstrate a novel role for Vif in cell cycle regulation and suggest that Vif and Vpr independently drive G 2 arrest in HIV-1 infected cells. Our results may have implications for the actions and interactions of key HIV-1 accessory proteins in AIDS pathogenesis.

Jun 1, 2004 · The viral infectivity factor (Vif) of HIV type-1 (HIV-1) is essential for efficient viral replication, yet was, until recently, enigmatic. This resulted from the complexity and cellular specificity of its function and the correspondingly complex systems that are required for …

HIV counteracts this intrinsic immune response by encoding a protein termed viral infectivity factor (Vif). Vif targets A3 to an E3 ubiquitin ligase complex for poly‐ubiquitination and proteasomal degradation. Vif is unique in that it can recognize and counteract multiple A3 …

The HIV-1 viral infectivity factor (Vif), one of the six accessory proteins, is essential for viral replication and pathogenesis. Its main function is to form Vif-Cullin5-ElonginBC complex and then is able to ubiquitinate and degrade the human anti-viral factor APOBEC3G, which markedly enhances the …

Jun 24, 2008 · HIV-1 Vif is a 23KD viral accessory protein that is required for production of infectious virus in a cell type-specific manner [1, 2]. Viruses lacking a functional vif gene are severely restricted in their ability to replicate in non-permissive cell types when compared to …

Jul 1, 1995 · Conceivably, therapeutic agents that block Vif’s ability to interact with vimentin are likely to interfere with the transport of the pre-integration complex to the nucleus, and dramatically affect the ability of HIV to efficiently infect lymphocytes.