The FDA maintains that leg cramps are not a serious health problem, while quinine can be lethal. Over the years, more than 90 people have died of quinine complications. Restricting Quinine Prescriptions: Despite this, nearly two million Americans took quinine to relieve their leg cramps.

Feb 1, 2016 · Quinine is moderately effective in decreasing the frequency and intensity of muscle cramps, but it is also associated with an increase in minor adverse effects. In addition, there is a risk of...

Nocturnal leg cramps are painful involuntary muscle contractions that usually occur while the patient is recumbent. They are a common condition, occurring in 70% of elderly persons at one time or another. 1 Many nonpharmacologic and pharmacologic treatments have been proposed, 2 the most studied therapy being quinine taken at bedtime.

One trial, a multi-centered, double-blind study, compared the Q-Vel combo product (quinine sulfate 64.8 mg and vitamin E 400 I.U.) to quinine sulfate, vitamin E, and placebo in 205 patients with a history of nocturnal leg muscle cramps.

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Feb 6, 2024 · Varicose veins most often affect the veins in the legs. That's because standing and walking increase the pressure in the veins of the lower body. For many people, varicose veins are simply a cosmetic concern. So are spider veins, a common, mild form of varicose veins. But varicose veins can cause aching pain and discomfort.