VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. In addition to binding to VEGFRs, VEGF binds to receptor complexes consisting of both neuropilins and VEGFRs.

Vascular endothelial growth factor receptors (VEGFRs) are part of the evolutionarily conserved VEGF signalling pathways that regulate the development and maintenance of the body’s cardiovascular and lymphovascular systems. VEGFR3, encoded by the ...

Dec 18, 2014 · Objectives—Vascular endothelial growth factor receptor 3 (VEGFR3) plays important roles both in lymphangiogenesis and angiogenesis. On stimulation by its ligand VEGF-C, VEGFR3 is able to form both ...

Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3), a receptor tyrosine kinase encoded by the FLT4 gene, plays a significant role in the morphogenesis and maintenance of lymphatic vessels. Under both normal and pathologic conditions, ...

Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals are transduced by VEGFC/D via VEGFR3. VEGFR3 also regulates sprouting angiogenesis ...

Jul 27, 2016 · This paper provides evidence for an important role for VEGFR3 expressed in tip cells to reinforce Notch signalling, thereby regulating branching morphogenesis in the blood vasculature.

Jannaway et al. show that vascular endothelial growth factor receptor 3 (VEGFR3) expression is required for the formation of button junctions and that NOTCH1 signaling can fully rescue button formation in the absence of VEGFR3.

Feb 13, 2025 · The receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) is the principal transmembrane receptor responsible for sensing and coordinating cellular responses to environmental lymphangiogenic stimuli in lymphatic endothelial cells (LECs).

VEGFR3 internalisation from the cell surface is regulated by ephrinB2 and intracellular proteins including ARRB1, epsins 1 and 2 and AGS8. VEGFR3 is also activated by mechanical stimuli including flow and tension in a ligand-independent manner.

Jul 7, 2021 · VEGFR3, encoded by the FLT4 gene, has an indispensable and well-characterized function in development and establishment of the lymphatic system. Autosomal dominant VEGFR3 mutations, that prevent the receptor functioning as a homodimer, cause one of the major forms of hereditary primary lymphoedema; Milroy disease.