Vav1: a key signal transducer downstream of the TCR - PubMed
Vav1 is a 95-kDa protein expressed in all hemopoietic cells that becomes rapidly tyrosine phosphorylated following T cell antigen receptor (TCR) stimulation. Vav1 contains multiple …
Vav1 Transduces T Cell Receptor Signals to the Activation of ...
Vav1 is a signal transducing protein required for T cell receptor (TCR) signals that drive positive and negative selection in the thymus. Furthermore, Vav1-deficient thymocytes show greatly …
Vav1 regulates T cell activation through a feedback mechanism …
In mature T cells, Vav1 deficiency reduces TCR-induced proliferation, intracellular Ca 2+ flux, upregulation of activation markers, and cytokine secretion (18, 20–25). Vav1 is also required …
The costimulatory molecule CD226 signals through VAV1 to amplify TCR …
Engagement of CD226 induced the tyrosine phosphorylation of VAV1 and synergized with T cell receptor (TCR) signals to specifically enhance the production of interleukin-17 (IL-17) by …
Function of the Nucleotide Exchange Activity of Vav1 in T Cell ...
Vav1 is an important mediator of T cell receptor (TCR) signaling and is required for the development of T cells in the thymus and for their activation and proliferation in response to …
Mechanism and function of Vav1 localisation in TCR signalling
The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) signalling, leading to the activation of multiple pathways. We now show that it is recruited to …
Mechanism and function of Vav1 localisation in TCR signalling
Nov 15, 2012 · The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) signalling, leading to the activation of multiple pathways. We now show that it …
The Amino-Terminus of Vav1 Regulates TCR-Induced SLP-76 …
Vav1 is a proto-oncogene that plays crucial roles in the signaling pathways initiated by the T cell receptor (TCR) (1). Vav1 regulates T cell proliferation and effector function through its impacts …
Vav1 Regulates T-Cell Activation through a Feedback Mechanism …
Jul 2, 2015 · Vav1, a Rac/Rho guanine nucleotide exchange factor and a critical component of the T-cell receptor (TCR) signaling cascade is tyrosine phosphorylated rapidly in response to T …
Vav1 Promotes T Cell Cycle Progression by Linking TCR/CD28 ...
Oct 15, 2006 · In this study, we report three novel findings regarding the regulation of FOXO1 in T cells: 1) the activity of FOXO1 is tightly regulated upon TCR/CD28 engagement; 2) Vav1 is an …