Mar 15, 2014 · In this article, we provide evidence that Vav1, a member of the RhoGEF family, plays a crucial role in macrophage activation and septic endotoxemia. Vav1-deficient mice …

Here, we provide evidence that Vav1, a member of the RhoGEF family, plays a crucial role in macrophage activation and septic endotoxemia. Vav1 deficient mice demonstrated a …

Mar 15, 2014 · In this article, we provide evidence that Vav1, a member of the RhoGEF family, plays a crucial role in macrophage activation and septic endotoxemia. Vav1-deficient mice …

Jul 15, 2005 · Vav1-mutant mice generate defective humoral immunoglobulin G (IgG) responses following administration of low doses of LPS but respond normally to higher doses, while mice …

In this study, we tested the role of vav1 in macrophage responses to LPS, focusing on the upregulation of nuclear factor for interleukin-6 expression (NF-IL-6) activity and inducible nitric …

We and others have reported previously that vav1 undergoes rapid tyrosine phosphorylation in response to macrophage activation by LPS. In addition, we observed that vav1 was physically …

Feb 1, 2011 · We propose that either P-Rex1 or Vav1 alone can produce sufficient active Rac for GPCR-dependent cell responses but, under normal circumstances, both contribute, …

Jul 1, 2009 · Total cellular lysates from day 8 DCs treated with LPS (lanes 2 and 4) or media alone (lanes 1 and 3) were resolved by SDS-PAGE and detected by Western blot using Vav1-, …

In this study, we tested the role of vav1 in macrophage responses to LPS, focusing on the upregulation of nuclear factor for interleukin-6 expression (NF-IL-6) activity and inducible nitric …

Here, we identify the Vav family of Rho guanine nucleotide exchange factors (GEFs) as critical mediators of LPS-induced MyD88-dependent activation of Rac2, NADPH oxidase, and ROI …