Vascular endothelial growth factor (VEGF) is an important signaling protein involved in both vasculogenesis (the formation of the circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature).

Vascular endothelial growth factor (VEGF, / v ɛ dʒ ˈ ɛ f /), originally known as vascular permeability factor (VPF), [1] is a signal protein produced by many cells that stimulates the formation of blood vessels.

The vascular endothelial growth factor (VEGF) and its receptor (VEGFR) have been shown to play major roles not only in physiological but also in most pathological angiogenesis, such as cancer. VEGF belongs to the PDGF supergene family characterized ...

One of the most important growth and survival factors for endothelium is vascular endothelial growth factor (VEGF). 4 VEGF induces angiogenesis and endothelial cell proliferation and it plays an important role in regulating vasculogenesis.

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and was first described as an essential growth factor for vascular endothelial cells. VEGF is up-regulated in many tumors and its contribution to tumor angiogenesis is well defined.

Jun 1, 2003 · Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in...

Jul 27, 2016 · Vascular endothelial growth factor receptor (VEGFR) signalling is tightly regulated at different levels: ligand and receptor expression, the presence of co-receptors and accessory...

While three VEGF Rs have been identified (VEGF R1, VEGF R2, and VEGF R3), signaling through VEGF R2 is strongly associated with the initiation of angiogenesis. VEGF R2 is highly expressed by vascular endothelial cells and their embryonic precursors.

Vascular endothelial growth factor and its receptor (VEGF-VEGFR) system play a critical role in the regulation of angiogenesis and lymphangiogenesis in vertebrates.

Mar 7, 2019 · The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our understanding of vasculogenesis and angiogenesis during development and physiological homeostasis.