Urate oxidase is formulated as a protein drug (rasburicase) for the treatment of acute hyperuricemia in patients receiving chemotherapy. A PEGylated form of urate oxidase, pegloticase, was FDA approved in 2010 for the treatment of chronic gout in adult patients refractory to "conventional therapy". [16]

Uric acid is the final product of purine metabolism and is converted to allantoin in most mammals via the uricase enzyme. The accumulation of loss of function mutations in the uricase gene rendered hominoids (apes and humans) to have higher urate concentrations compared to …

Uricases are being used to treat uncontrolled gout, and can achieve rapid reduction of hyperuricaemia, dramatic resolution of tophi, decreased chronic joint pain and improved quality of life. Availability, cost and uricase immunogenicity have limited their use.

Krystexxa ® is a hyper-PEGylated pig-baboon chimeric uricase indicated for chronic refractory gout that induces an immunogenic response in 91% of treated patients, including infusion reactions (26%) and anaphylaxis (6.5%). These properties limit its use and effectiveness.

Uricase, also known as urate oxidase, is an enzyme that catalyzes the degradation of uric acid to 5-hydroxyisourate and allantoin, both of which are readily excreted from the body [1].

5 days ago · The meaning of URICASE is an enzyme that promotes oxidation of uric acid to allantoin, carbon dioxide, and other products and that is found especially in the liver, kidney, and brains of most animals other than primates.

Jul 18, 2018 · Uricases include pegloticase and rasburicase; the former used in the treatment of gout and the latter used principally to prevent the sequelae of hyperuricaemia in tumour lysis syndrome (2). Pegloticase is produced from genetically modified E coli (2,3). It is administered twice-weekly by intravenous injection in a healthcare setting (3).

Nov 14, 2024 · In this study, we constructed engineered macrophages that stably expressed uricase, which might serve as a promising alternative to the direct injection of uricases. Materials and Methods: Engineered macrophages RAW264.7 cells were injected intravenously to treat hyperuricemic KM mice.

Aug 3, 2023 · Anaerobic bacteria of the gut microbiome are able to metabolize uric acid, compensating for the uricase deficiency of their host. This conversion of uric acid to xanthine or SCFAs is important for maintaining low levels of uric acid in serum, lowering gout risk.

Sep 8, 2023 · Uricases are being used to treat uncontrolled gout, and can achieve rapid reduction of hyperuricaemia, dramatic resolution of tophi, decreased chronic joint pain and improved quality of life....