Interleukin 31 mediates MAP kinase and STAT1/3 activation in
IL31 mediates ERK-1/2, Akt, STAT1, and STAT3 activation in IEC resulting in enhanced IEC migration. However, at low cell density, IL31 had significant antiproliferative capacities (p<0.005).
Interleukin-31 and Oncostatin-M Mediate Distinct ... - ScienceDirect
Feb 2, 2007 · The IL-31Rα cDNA was amplified from RNA extracted from human glioma cell line U87 and cloned into pCMV-Tag 4A (Stratagene, La Jolla, CA) vector between the HindIII and …
The antiangiogenic role of the pro-inflammatory cytokine …
We found that Interleukin-31 (IL31), a protein belonging to the pro-inflammatory IL-6 cytokine family, was upregulated in the plasma and bone marrow cells following PTX and FOLFOX …
The IL-31/IL-31 receptor axis: general features and role in …
IL-31 is produced predominantly by circulating Th2 lymphocytes and skin-homing CLA + CD45RO + T cells. Studies in humans have demonstrated a pathogenic role for IL-31 in atopic …
Structures and biological functions of IL-31 and IL-31 receptors
IL-31 acts on a broad range of immune- and non-immune cells and therefore possesses potential pleiotropic physiological functions, including regulating hematopoiesis and immune response, …
IL-31-dependent neurogenic inflammation restrains cutaneous …
Oct 20, 2023 · Our data support a model wherein IL-31 activation of IL31RA + pruritoceptors triggers release of calcitonin gene-related protein (CGRP), which can mediate neurogenic …
IL-31: State of the Art for an Inflammation-Oriented Interleukin
The results showed that IL-31 plays a crucial role in the pathogenesis of systemic skin manifestations, prognosis, and itch severity. Traditional therapies target this interleukin …
Based on the effects of ectopic expression in transgenic mice, IL-31, a CD4 T-cell-derived cytokine, has been associated with pruritis and dermatitis affecting dermal keratinocytes and …
Stat3 activation is required for the growth of U87 cell-derived …
To unfold the contribution of activated Stat3 to the growth of GBM, we generated human GBM cell line (U87)- derived stable clones expressing a dominant negative mutant (DN)-Stat3 in a …
Interleukin-31 promotes fibrosis and T helper 2 polarization in ...
Oct 12, 2021 · Interleukin (IL)-31 has been implicated in fibrosis and T helper (Th) 2 immune responses, both of which are characteristics of SSc. The exact role of IL-31 in SSc …