RANKL is identified as a part of the TNF family; RANKL is specifically categorized under the TNFSF11, the TNF ligand superfamily member. RANKL is composed of 314 amino acids and …

Mar 30, 2025 · TNFSF11 (TNF Superfamily Member 11) is a Protein Coding gene. Diseases associated with TNFSF11 include Osteopetrosis, Autosomal Recessive 2 and Autosomal …

Gene ID: 8600, updated on 8-Feb-2025. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor …

Nov 27, 2018 · In the recent two decades, it has been well elucidated that receptor activator of nuclear factor-κB ligand (RANKL; also known as TNFSF11) binding to its receptor RANK (also …

Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and …

Jan 4, 2025 · Title: Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma. Osteoprotegerin and receptor activator of the …

Apr 9, 2024 · By utilizing gene knockdown or overexpression assays, we found that TNFSF11 was negatively associated with GPX4. Furthermore, cells with TNFSF11 overexpression were …

Feb 8, 2025 · Enables identical protein binding activity; receptor ligand activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including …

The cytokine receptor activator of nuclear factor kappa B ligand (RANKL), encoded by the Tnfsf11 gene, is essential for osteoclastogenesis and previous studies have shown that deletion of the …

The deletion results in a frameshift and a premature termination codon predicted to cause loss of the beta-G, beta-H, and beta-F strands of TNFSF11, which are important for its trimerization.