Mar 3, 2025 · SUVmax, TMTV, and TLG are independent prognostic factors in ENKTL. Our new model, which integrates 18F-FDG PET/CT metrics with clinical data, enhances survival prediction and may support personalized treatment strategies, though further validation is required.

Apr 16, 2020 · TMTV was computed on baseline positron emission tomography/computed tomography using the 41% maximum standardized uptake value method; the optimal TMTV cutoff for progression-free (PFS) and overall survival (OS) was determined and confirmed by a training validation method.

The optimal cut-points to identify patients with TTT within 24 months were 14 for TMTV (AUC 0.70; 95% CI 51–88) and 64 for WB-TLG (AUC 0.71; 95% CI 52–89) (p < 0.005). The probability of not having started treatment within 24 months was …

Jan 17, 2024 · Patients with high TMTV exhibited significantly inferior 2-year PFS and OS, with rates of 22.4% and 38.1%, respectively, compared to those with low TMTV, who had rates of 85.8% and 95.0% (both P < 0.001).

Dec 16, 2024 · We aimed to explore the predictive value of total metabolic tumor volume (TMTV) and beta-2-microglobulin (B2M) levels in patients with follicular lymphoma (FL) with a high tumor burden receiving standard first-line immunochemotherapy.

We searched PubMed, EMBASE and Cochrane to identify studies assessing the effect of baseline TMTV and TLG on the survival of lymphoma patients. Pooled hazard ratios (HR) for overall survival (OS) and progression-free survival (PFS) were …

Jun 1, 2024 · We developed an end-to-end deep learning (DL) model for automatic lesion segmentation and TMTV quantification from FDG-positron emission tomography/computed tomography (FDG-PET/CT) scans.

Nov 29, 2018 · In all evaluated patients, a significant impact of TMTV for cut-offs of >300 vs ≤300 cm3 was observed for PFS (HR=2.09; 95% CI, 1.22-3.69) and OS (HR=2.99; 95% CI, 1.44-6.18). Patients with high TMTV >300 cm3 vs low TMTV ≤300 cm3, respectively, had a 4-year PFS of 57% vs 73% and OS of 70% vs 88%.

According to research published in Blood, though, baseline total metabolic tumor volume (TMTV) as assessed by positron emission tomography (PET) appears to be a better tool for stratifying early response among patients with early-stage HL.

High baseline TMTV (±ECOG) was a strong prognosticator of inferior PFS and OS in REMARC patients post-R-CHOP, irrespective of maintenance. Abstract. Early identification of ultra-risk diffuse large B-cell lymphoma (DLBCL) patients is needed to …