According to research published in Blood, though, baseline total metabolic tumor volume (TMTV) as assessed by positron emission tomography (PET) appears to be a better tool for stratifying early response among patients with early-stage HL.

Our findings suggest that BVG, TLG, TMTV, and Ki-67 are independent prognostic indicators for survival in patients with pre-treatment DLBCL, especially BVG, which is a novel prognostic indicator that has to be validated in future research.

High baseline TMTV (±ECOG) was a strong prognosticator of inferior PFS and OS in REMARC patients post-R-CHOP, irrespective of maintenance. Early identification of ultra-risk diffuse large B-cell lymphoma (DLBCL) patients is needed to aid stratification to innovative treatment.

A Follicular lymphoma patients with both TMTV ≥ 14 and intermediate-high FLIPI (≥ 2) have only an 18% probability of not having starting treatment at 36 months (95% CI 3–44) while patients with TMTV < 14 and FLIPI ≥ 2 have 75% probability …

Mar 29, 2018 · Total metabolic tumor volume (TMTV) was measured on baseline PET. iPET2 findings were reported negative (DS1-3) or positive (DS4-5) with the Deauville scale (DS). The prognostic value of TMTV was evaluated and compared with baseline characteristics, staging classifications, and iPET2.

Jan 17, 2024 · We performed a retrospective analysis on 141 patients with LUAD (74 males, 67 females, median age 67 (range 34–86)) who underwent 18 F-FDG PET/CT and had their EGFR mutation status determined. Optimal cutoff points for TMTV were determined using time-dependent receiver operating characteristic curve analysis.

The total metabolic tumor volume (TMTV) was computed using the 41% SUV max method. Results: With a median follow-up of 6.5 years, the 6-year progression-free survival (PFS) was 57.8%, the median TMTV was 284 cm 3, SUV max was 11.3 and SD max was 0.32 m-1, with no significant difference between arms.

Dec 16, 2024 · We aimed to explore the predictive value of total metabolic tumor volume (TMTV) and beta-2-microglobulin (B2M) levels in patients with follicular lymphoma (FL) with a high tumor burden receiving standard first-line immunochemotherapy.

May 20, 2016 · Conclusions: TMTV predicts the outcome of young advanced HL pts independently of the early metabolic response to treatment. The combination of TMTV and PET2 allows identifying 3 subsets of HL pts with significantly different outcome that may help clinician to better tailor therapy.

Dec 1, 2021 · Baseline TMTV appears to be a useful independent prognostic factor for predicting relapse in advanced-stage HL in ABVD subgroup, with a tendency of survival curves separation in BEACOPP subgroup.