Using a ROC analysis, we found an optimal cut-off value for TTT within 24 months of 14 for TMTV (sensitivity 67%, specificity 75%, AUC 0.70, 95% CI 51–88) and of 64 for WB-TLG (sensitivity 67%, specificity 72%, AUC 0.71, 95% CI 52–89).

High baseline TMTV (±ECOG) was a strong prognosticator of inferior PFS and OS in REMARC patients post-R-CHOP, irrespective of maintenance. Abstract. Early identification of ultra-risk diffuse large B-cell lymphoma (DLBCL) patients is needed to …

High total metabolic tumor volume (TMTV), computed from baseline 18 F-fluorodeoxyglucose–positron emission tomography (PET), is associated with shorter progression-free survival (PFS), but circulating tumor cells (CTCs) and cell-free DNA (cfDNA) may also reflect tumor burden and be of prognostic value.

Dec 16, 2024 · We aimed to explore the predictive value of total metabolic tumor volume (TMTV) and beta-2-microglobulin (B2M) levels in patients with follicular lymphoma (FL) with a high tumor burden receiving standard first-line immunochemotherapy.

Jan 17, 2024 · The parameter with the highest predictive value in both PFS and OS was TMTV; therefore, it was chosen to evaluate prognostic significance in our studies. The optimal cutoff values for TMTV were determined to be 36.42 and 37.51 cm 3 …

Feb 2, 2022 · The optimal cut-off for predicting risk using TMTV depends on the selected TMTV segmentation method, population characteristics, and treatment. A high TMTV at baseline PET/CT was associated with worse progression-free survival (PFS) and overall survival (OS) in early-stage cHL.

TMTV, TLG, and SUV max were centrally determined by three experienced nuclear medicine physicians from each baseline PET/CT scan collected in real time during the study. TMTV was calculated using a tumor threshold of 1.5 times the mean SUV of the liver +2 standard deviations.

Baseline TMTV and TLG are strong predictors of PFS and OS in FL. Furthermore, interim TMTV (ΔTMTV > 66.3%) and TLG (ΔTLG > 64.5%) reduction are valuable tools for early treatment response assessment in FL patients.

Aug 12, 2022 · The determination of total metabolic tumor volume (TMTV) is generally based on semi-automatically defined volumes of interest (VOI) around the tumor using a software visualization program; however, often these VOIs are manually adjusted by the nuclear medicine specialist to include the entire tumor and avoid healthy tissues.

TMTV-Net demonstrates strong performance and generalizability in TMTV segmentation across multi-site external datasets, encompassing various lymphoma subtypes.