One such parameter is total metabolic tumor volume (TMTV), which is the total 3-dimensional volume of all FDG-avid lesions on PET-CT. 25,34 TMTV has been found in 1 study to be an independent predictor of outcome in grade 1 to 3 high tumor burden FL, 35 but not predictive of outcome in another study of favorable grade 1 to 2 FL. 36 A second PET ...

Jan 17, 2024 · The optimal cutoff values of TMTV were 36.42 cm 3 for PFS and 37.51 cm 3 for OS. Patients with high TMTV exhibited significantly inferior 2-year PFS and OS, with rates of 22.4% and 38.1%, respectively, compared to those with low TMTV, who had rates of 85.8% and 95.0% (both P < 0.001).

Disease burden is a critical determinant of outcomes in CAR‐T therapy for B‐cell lymphomas, and one of the most widely used techniques for its assessment is Total Metabolic Tumor Volume (TMTV) measured via [18 F]FDG PET/CT. Biological …

Several of these studies have reported the value of total metabolic tumor volume (TMTV) as a negative or positive prognostic indicator, based on a TMTV above or below a predetermined threshold at baseline, or as an indicator of response according to a change in TMTV over a course of treatment.

Dec 12, 2022 · The TMTV/Eastern Cooperative Oncology Group-PS combination outperformed the International Prognostic Index with a positive C-index for progression-free survival and overall survival in most series. The combination of high TMTV > 220 cm 3 and ECOG-PS ≥ 2 is a simple clinical model to identify aggressive LBCL risk categories before treatment ...

Baseline TMTV is a strong prognostic factor of POD24 and PFS in advanced FL, even in the era of antibody maintenance. SUV max was not predictive of PFS in either treatment arm. TMTV combined with FLIPI score identified a subgroup of patients (16%) at high risk of relapse with a 6-year PFS of 41.0%.

Apr 16, 2020 · Early identification of ultra-risk diffuse large B-cell lymphoma (DLBCL) patients is needed to aid stratification to innovative treatment. Previous studies suggested high baseline total metabolic tumor volume (TMTV) negatively impacts survival of DLBCL patients.

TMTV, TLG, and SUV max were centrally determined by three experienced nuclear medicine physicians from each baseline PET/CT scan collected in real time during the study. TMTV was calculated using a tumor threshold of 1.5 times the mean SUV of the liver +2 standard deviations.

Mar 14, 2025 · Results: The optimal cutoff value for TMTV was 40.13 ml. The survival rates of patients varied significantly across stages I (n = 164), II (n = 37), III (n = 46), and IV (n = 137); however, there was no statistically significant difference between stages II and III (P = 0.440).

TMTV-Net demonstrates strong performance and generalizability in TMTV segmentation across multi-site external datasets, encompassing various lymphoma subtypes.