Nov 5, 2024 · Total metabolic tumor volume (TMTV) derived from positron emission tomography/computed tomography (PET/CT) data has been shown to serve as an accurate tumor burden surrogate and be associated with outcomes in FL (Cottereau et al. Ann Oncol 2024).

High total metabolic tumor volume (TMTV), computed from baseline 18 F-fluorodeoxyglucose–positron emission tomography (PET), is associated with shorter progression-free survival (PFS), but circulating tumor cells (CTCs) and cell-free DNA (cfDNA) may also reflect tumor burden and be of prognostic value.

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Jun 1, 2024 · We developed an end-to-end deep learning (DL) model for automatic lesion segmentation and TMTV quantification from FDG-positron emission tomography/computed tomography (FDG-PET/CT) scans.

Mar 14, 2025 · The TNM staging system demonstrates robust prognostic utility in patients with LUAD, while the incorporation of baseline TMTV may offer additional risk stratification within distinct TNM stages.

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Several of these studies have reported the value of total metabolic tumor volume (TMTV) as a negative or positive prognostic indicator, based on a TMTV above or below a predetermined threshold at baseline, or as an indicator of response according to a change in TMTV over a course of treatment.

High baseline TMTV (±ECOG) was a strong prognosticator of inferior PFS and OS in REMARC patients post-R-CHOP, irrespective of maintenance. Early identification of ultra-risk diffuse large B-cell lymphoma (DLBCL) patients is needed to aid stratification to innovative treatment.

Aug 1, 2024 · Pretreatment total metabolic tumor volume (TMTV), measured using 18 F-FDG PET/CT, provides prognostic information, and TMTV, alone or in combination with other clinical risk factors, outperforms commonly used international prognostic scores (2,6–11).