Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that includes matrix metalloproteinases (MMPs), a disintegrin and ...

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene. [5][6] This gene belongs to the tissue inhibitor of metalloproteinases gene family.

Mar 30, 2025 · Complete information for TIMP3 gene (Protein Coding), TIMP Metallopeptidase Inhibitor 3, including: function, proteins, disorders, pathways, orthologs, and expression.

TIMP3 exerts antitumour effects via matrix metalloproteinase (MMP)-dependent and MMP-independent pathways. Due to promoter methylation and miRNA binding, TIMP3 expression has been observed to decrease in various cancers. Consequently, the migration and invasion of cancer cells increases.

Among the four mammalian TIMPs, TIMP-3 has the largest inhibitory profile being able to inhibit not only MMPs and ADAMTSs, but also all the canonical sheddases of the ADAM and MT-MMP families, thus rendering TIMP-3 a master regulator of ectodomain shedding.

TIMP-3 promotes apoptosis in melanoma cells through stabilization of three distinct death receptors and activation of their apoptotic signaling cascade through caspase-8. Decreased expression of TIMP-3 protein correlates with invasive activity and metastasis in esophageal squamous cell carcinoma

Oct 2, 2018 · The tissue inhibitor of metalloproteinases-3 (TIMP-3) is a major regulator of extracellular matrix turnover and protein shedding by inhibiting different classes of metalloproteinases,...

Dec 21, 2019 · Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis.

Jun 16, 2020 · Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10.

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