Apr 6, 2021 · The induction of type I interferons through the transcription factor interferon regulatory factor 3 (IRF3) is considered a major outcome of stimulator of interferon genes …

Apr 13, 2020 · TBK1 phosphorylates IRF3, causing it to dimerize and move into the nucleus, where it induces transcription of genes encoding various cytokines, interferons, and chemokines.

Here we show that STING stimulates IRF3 phosphorylation by the kinase TBK1 in an in vitro reconstitution system. Using this system, we identified a carboxyl terminal region of STING …

Apr 14, 2003 · Here we report that the noncanonical IκB kinase homologs, IκB kinase-ε (IKKε) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-κB activation, are …

We found that the regulation of IRF3 by small GTPases was dependent on TBK1. Our work reveals the significant contribution of GTPases in IRF3 signaling and the potential role of IRF3 …

6 days ago · PrPC activates TBK1-IRF3 signaling to worsen renal fibrosis in mice, highlighting amlexanox as a potential therapeutic for chronic kidney disease.

Feb 21, 2024 · We found that DUSP4 regulates the activation of TBK1 and ERK1/2 in a signalling complex containing DUSP4, TBK1, ERK1/2 and IRF3 to regulate the production of type I IFNs. …

TBK1 (TANK-binding kinase 1) is a noncanonical IκB protein kinase that phosphorylates and activates downstream targets such as IRF3 and c-Rel and, mediates NF-κB activation in cancer.

Tumor necrosis factor α (TNFα) and interleukin-1β (IL-1β), which are regulated by both IRF3 and NF-κB, were down-regulated in the tumors of all STING mutant mice (SI Appendix, Fig. S9 C), …

Mar 6, 2012 · Here, we showed that STING stimulates phosphorylation of IRF3 by the kinase TBK1 (TANK-binding kinase 1) in an in vitro reconstitution system. With this system, we …