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Studies have demonstrated that IgA endomysial antibody tests have >99% specificity for gluten-sensitive enteropathy. 1 Recently, the endomysial antigen has been identified as the protein cross-linking enzyme known as tissue transglutaminase (tTG). 2

Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC 2.3.2.13) of the protein-glutamine γ-glutamyltransferases family (or simply transglutaminase family).

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Jun 7, 2024 · A tissue transglutaminase IgA (or, tTg-IgA) test helps doctors diagnose celiac disease. If you have celiac disease, your immune system is triggered when you eat gluten.

Tissue Transglutaminase (tTG) Antibody (IgA) - Tissue Transglutaminase Antibody, IgA, is useful in diagnosing gluten-sensitive enteropathies, such as Celiac Sprue Disease, and an associated skin condition, dermatitis herpetiformis.

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Tissue transglutaminase (tTG) is capable of binding and hydrolyzing GTP, as well as catalyzing an enzymatic transamidation reaction that crosslinks primary amines to glutamine residues. tTG adopts two vastly different conformations, depending on ...

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