TSC1 - Wikipedia
Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene. [5] TSC1 functions as a co-chaperone which inhibits the ATPase activity of …
Tuberous sclerosis - Symptoms and causes - Mayo Clinic
Dec 6, 2022 · Tuberous sclerosis is a genetic disorder caused by gene changes — sometimes called mutations — in either the TSC1 or the TSC2 gene. These genes are thought to prevent …
TSC1 Gene - GeneCards | TSC1 Protein | TSC1 Antibody
Mar 30, 2025 · TSC1 (TSC Complex Subunit 1) is a Protein Coding gene. Diseases associated with TSC1 include Tuberous Sclerosis 1 and Lymphangioleiomyomatosis. Among its related …
TSC1 gene - MedlinePlus
The TSC1 gene provides instructions for producing a protein called hamartin. Within cells, hamartin interacts with a protein called tuberin, which is produced from the TSC2 gene. These …
Role of TSC1 in physiology and diseases - PubMed
TSC1, an essential component of the pro-survival PI3K/AKT/MTOR signaling pathway, plays an important role in processes like development, cell growth and proliferation, survival, autophagy …
TSC1 and TSC2 gene mutations and their implications for …
Tuberous sclerosis is caused by the mutation of one of two tumor suppressor genes, TSC1 or TSC2. Currently, the development of novel techniques and great advances in high-throughput …
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC (tuberous sclerosis complex). Their gene products form a complex that has become the focus …
TSC1 TSC complex subunit 1 [ (human)] - National Center for ...
Gene ID: 7248, updated on 9-Feb-2025. This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the …
Tsc1 expression by dendritic cells is required to preserve T-cell ...
Recent evidence highlights a critical role of tuberous sclerosis complex 1 (Tsc1), a primarily upstream negative regulator of mammalian target of rapamycin (mTOR), in DC development, …
TSC1 TSC complex subunit 1 [ Homo sapiens (human) ]
Title: Tuberous sclerosis complex-1 (TSC1) contributes to selective neuronal vulnerability in Alzheimer's disease. TSC/MTOR mutated renal cell carcinoma with leiomyomatous stroma is …