Jun 28, 2013 · The overexpression of TRAF2 augmented the cytoplasmic expression of TRAF4 which promoted cell proliferation and inhibited cell apoptosis by activating NF-κB nuclear …

Jun 13, 2013 · Phosphorylation of TRAF2 (at Ser11 and Ser55 by PKCζ or IKKϵ, and at Thr117 by PKCδ and PKCϵ), which promotes K63-linked ubiquitination of TRAF2 and NF-κB activation, …

The structures of the TRAF domain of TRAF2, TRAF3, and TRAF6 and their receptor complexes were elucidated around year 2000 (24–26), and those of TRAF1, TRAF4, and TRAF5 and …

TRAF4. Unique among the TRAF family, TRAF4 is mainly involved in developmental, morphogenic, and oncogenic processes [148–153]. However, TRAF4 also regulates …

Gain-of-function alterations (gene amplification and overexpression) are common for TRAF1, TRAF4, TRAF5, and TRAF6 in human cancers, and are also identified for TRAF2 in epithelial …

TNF-associated factor 2 (TRAF2), a 56kD protein, was discovered through yeast two hybrid screening for proteins interacting with the c-terminal region of human TNF receptor 2. 1 Along …

Jun 28, 2013 · In this study, we examined the regulation function of TRAF2 to the cytoplasmic/nuclear distribution of TRAF4 in the breast cancer cell line. Using cell …

TRAF2 regulates the biology of breast cancer cells via the Akt signaling pathway. In MCF-7 and BT-549 cell lines, regulation of TRAF2 expression significantly affected the extent of Akt …

Jan 2, 2019 · TRAF2, a RING finger adaptor protein, plays an important function in tumor necrosis factor (TNF)- and TNF-like weak inducer of apoptosis (TWEAK)-dependent signaling, in …

Dec 25, 2024 · TRAF4 (TNF Receptor Associated Factor 4) is a Protein Coding gene. Diseases associated with TRAF4 include Lung Cancer and Intraneural Perineurioma. Among its related …