Function of TRADD in tumor necrosis factor receptor 1 ... - Nature
Jul 20, 2008 · Thus, TRADD is an essential component of TNFR1 signaling and has a critical but apparently cell type–specific function in TRIF-dependent TLR responses. Tumor necrosis …
The role of TRADD in death receptor signaling - PMC
TNFR1, being the main receptor transducing the signals from TNFα, is one of the best-studied receptors in the TNFR superfamily. TNFα was initially characterized as a cytokine that can …
Death domain complex of the TNFR-1, TRADD, and RIP1 proteins …
Jan 24, 2014 · TNFR-1-associated death domain (TRADD) protein is an adapter molecule that bridges the interaction between TNFR-1 and receptor-interacting serine/threonine-protein …
Conformational states of TNFR1 as a molecular switch for receptor ...
By probing the interaction between the receptor and its downstream signaling molecule (TRADD) our findings support a new model of TNFR1 activation in which varying conformational states …
Redundant and receptor-specific activities of TRADD, RIPK1 …
Feb 11, 2019 · Based on these characteristics, we propose a model in which the death receptor-specific activities of TRADD, RIPK1, and FADD are traced back to their hierarchically different …
The function of TRADD in signaling via tumor necrosis factor …
By generating TRADD-deficient mice, we demonstrated that TRADD plays a significant role in tumor necrosis factor receptor-1 (TNFR1) signaling by orchestrating the formation of TNFR1 …
Function of TRADD in tumor necrosis factor receptor 1 ... - PubMed
Tumor necrosis factor receptor 1 (TNFR1) and Toll-like receptors (TLRs) regulate immune and inflammatory responses. Here we show that the TNFR1-associated death domain protein …
The TNF receptor 1-associated protein TRADD signals cell death …
May 19, 1995 · We have identified a novel 34 kDa protein, designated TRADD, that specifically interacts with an intracellular domain of TNFR1 known to be essential for mediating …
The Adaptor Protein TRADD Is Essential for TNF-Like Ligand …
May 1, 2011 · TNFR-associated death domain protein (TRADD) is a key effector protein of TNFR1 signaling. However, the role of TRADD in other death receptor (DR) signaling …
TRADD - Wikipedia
TRADD is an adaptor protein. The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A / TNFR1 and mediates programmed cell …