Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene. [5][6] This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF).

Mar 30, 2025 · TNFAIP3 (TNF Alpha Induced Protein 3) is a Protein Coding gene. Diseases associated with TNFAIP3 include Autoinflammatory Syndrome, Familial, Behcet-Like 1 and Familial Behcet-Like Autoinflammatory Syndrome. Among its related pathways are TNF signaling and Metabolism of proteins.

The Zinc finger protein A20, also known as tumor necrosis factor-alpha-induced protein 3 (TNFAIP3), is a dual-function enzyme which negatively regulates the NF-κB pathway and suppresses TNF-induced apoptosis (Heyninck et al., 1999).

The tumor necrosis factor-α-induced-protein 3 (TNFAIP3, also known as A20, located on 6q23.3), and its interacting protein named as TNFAIP3 interacting protein 1 (TNIP1, located on 5q33.1) are both key regulators of NF-κB signaling pathway, modulating cell …

Jul 14, 2014 · Activation of the NF-κB pathway is tightly controlled by several negative feedback mechanisms, including A20, an ubiquitin-modifying enzyme encoded by the tnfaip3 gene. Mice with selective deletion of A20 in myeloid, dendritic, or B cells recapitulate some human inflammatory pathology.

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity.

Oct 12, 2012 · A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts multiple intracellular signalling cascades. Recent studies in three general areas have converged to...

The TNFAIP3 gene encodes an ubiquitin-editing enzyme with a critical function in the inhibition of key proinflammatory molecules to negatively regulate inflammation and the immune response (summary by Aeschlimann et al., 2018).

Nov 14, 2024 · Title: Tumor Necrosis Factor Alpha-Induced Protein-3 Inhibits the Activation of Hepatic Stellate Cells by Regulating the p65 Molecule in the NF-κB Signaling Pathway. Down-regulation of A20 mRNA expression in peripheral blood mononuclear cells from MDS patients.

Jan 1, 2018 · It is a primary response gene located on chromosome 6q23, originally identified as a gene in human umbilical vein endothelial cells whose expression is rapidly induced by tumor necrosis factor (TNF). The 80 kDa protein encoded by TNFAIP3 is the zinc finger protein A20, which has both ubiquitin ligase and deubiquitinase activities.