IRF3 mediates a TLR3/TLR4-specific antiviral gene program
Selective activation of the TLR3/TLR4-IRF3 pathway potently inhibited viral replication. These results suggest that TLR3 and TLR4 have evolutionarily diverged from other TLRs to activate …
IRFs: master regulators of signalling by Toll-like receptors and ...
Sep 1, 2006 · By contrast, IRF3 has an essential role in the TRIF-dependent pathway of type I IFN gene induction by TLR4. IRFs interact with other transcription factors, such as NF-κB, and …
TLR signalling and activation of IRFs: revisiting old friends …
Sep 1, 2005 · TLR3 interacts directly with TRIF to trigger these Myd88-independent pathways. In addition, TLR3 interacts with PI3K and activates Akt, leading to further phosphorylation and …
The multiple roles of interferon regulatory factor family in health …
Oct 9, 2024 · In mammals, nine IRF members have been reported, 10 designated as IRF1 (also known as MAR), IRF2, IRF3, IRF4 (known alternatively as LSIRF/ICSAT/ PIP), IRF5, IRF6, …
A high throughput screening for TLR3-IRF3 signaling pathway …
Toll-like Receptor 3 (TLR3) is one of the major innate immune sensors of double stranded RNA (dsRNA). The signal transduction pathway activated by TLR3, upon binding to dsRNA, leads …
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll
Oct 6, 2003 · Toll-like receptor (TLR)3 and 4 activate these pathways to induce IFN-alpha/beta, regulated on activation, normal T cell expressed and secreted (RANTES), and gamma …
TLR pathways and IFN-regulatory factors: to each its own
TLR-3 and TLR-4 induce IFN-beta by activating IRF-3; TLR-9 induces IFN-alpha and IFN-beta through IRF-7, at least when engaged by type A CpG oligonucleotides (CpG-A) in …
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in ...
Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively …
LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 …
Oct 14, 2011 · TRIF and MyD88 deficient mice revealed that neuroprotection induced by LPS depends on TLR4 signaling via TRIF, which activates IRF3, but does not depend on MyD88 …
Double-stranded RNA mediates interferon regulatory factor 3 …
Our results indicate that astrocytes have a distinct TLR3 cytoplasmic expression pattern and directly respond to dsRNA, leading to activation of interferon regulatory factor 3 (IRF3), …