Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that has been established as a central mediator of kidney fibrosis. Emerging evidence demonstrates a complex scheme of …

Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) activation by TGF-β in mesangial cells. In the absence of TGF-β1 stimulation, TAK1 associates with TGF-β receptor type I …

Mar 22, 2025 · We show here for the first time that the MAP3K7 (TGF beta activated kinase, TAK1) is responsible for the synergistic costimulation of B cells by BCR and TLR9, resulting in …

Jan 9, 2019 · TGF-β-activated kinase 1 (TAK1), also known as MAPK kinase kinase 7, is one of the best characterized non-Smad signal transducers critical for TGF-β functions in EMT and …

Jan 5, 2021 · Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide …

Aug 29, 2014 · TGF-β-activated kinase 1 (TAK1) is a key kinase in mediating Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) signaling. Although TAK1 activation involves the …

Aug 31, 2008 · Our data show that TGF-β specifically activates TAK1 through interaction of TβRI with TRAF6, whereas activation of Smad2 is not dependent on TRAF6. TβRII and TβRI …

5 days ago · TAK1 has been shown to play a critical role in the activation of TGF-β-induced MKK3 and subsequent collagen production in mesodermal cells . Additionally, the expression of TGF …

Mar 20, 2014 · TGF-β family cytokines, such as TGF-β and BMP, have been shown to play critical roles in kidney development, 47 and TAK1 is an important mediator of TGF-β and BMP …

Here, we propose a mechanism whereby TAK1 is activated by TGF-β1 in primary mouse mesangial cells. Under unstimulated conditions, endogenous TAK1 is stably associated with …