As a major activator of transforming growth factor β (TGF-β), the RGD receptor αvβ8-integrin is involved in pathogenic processes related to TGF-β dysregulation, such as tumor growth, invasion, and radiochemoresistance, metastasis and tumor cell stemness, as well as epithelial-mesenchymal transition.

Jan 15, 2024 · For limiting fatty acid availability to BMSCs, we found that GPR84 antagonist 8 (GA8), a GPR84 protein antagonist, was used to inhibit the function of G protein-coupled receptor 84 (GPR84) protein (a valid target candidate as medium-chain fatty acid receptor).

Oct 31, 2020 · The novel positron emission tomography (PET) radiopharmaceutical Ga-68-Triveoctin for in vivo mapping of αvβ8-integrin expression might enhance the prognosis of certain tumor entities, as well as support and augment TGF-β-targeted therapeutic approaches.

Oct 31, 2020 · The novel positron emission tomography (PET) radiopharmaceutical Ga-68-Triveoctin for in vivo mapping of αvβ8-integrin expression might enhance the prognosis of certain tumor entities, as...

Feb 9, 2023 · B4GALT1-dependent galectin-8 binding with TGF-β receptor suppresses colorectal cancer progression and metastasis

Sep 4, 2024 · Depletion of galectin-8 promoted the migration of CRC cells by increasing TGF-β-receptor-mediated RAS and Src signaling, which was attenuated after recombinant galectin-8 treatment. Treatment...

Purpose: As a major activator of transforming growth factor (TGF- ), the RGD receptor v 8-integrin is involved in pathogenic processes related to TGF- dysregulation, such as tumor growth,...

Jan 13, 2025 · Methods and results Using cell surface markers applicable even into wild-type mouse lungs, we could classify PDGFRα⁺ total lung resident fibroblasts into at least two major distinct subpopulations:...

TGF-β serves as an antiproliferative agent and inhibits tumor development during primary stages of tumor progression; however, during the later stages, it encourages tumor development and mediates metastatic progression and chemoresistance.

Oct 31, 2020 · As a major activator of transforming growth factor β (TGF-β), the RGD receptor αvβ8-integrin is involved in pathogenic processes related to TGF-β dysregulation, such as tumor growth, invasion, and radiochemoresistance, metastasis and tumor cell stemness, as well as epithelial-mesenchymal transition.