Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa - tissue factor complex.

A promising target for restoring thrombin generation is tissue factor pathway inhibitor (TFPI), a multivalent Kunitz-type serine protease inhibitor that regulates tissue factor-induced coagulation via factor Xa-dependent feedback inhibition of the tissue factor-factor VIIa complex.

An inhibitor of tissue factor-induced coagulation was rediscovered in the 1980’s and subsequently named tissue factor pathway inhibitor (TFPI). Three isoforms of TFPI are transcribed through alternative mRNA splicing: TFPIα, which contains an acidic ...

inhibidor de la vía extrínseca (TFPI), y el inhibidor de proteasas dependiente de proteína Z (ZPI). La fi-gura 1 ilustra los sitios de acción de los principales inhibidores fisiológicos.

Tissue factor pathway inhibitor (TFPI) is an alternatively spliced anticoagulant protein that primarily dampens the initiation phase of coagulation before thrombin is generated. As such, TFPI’s actions are localized to cells expressing TF and to ...

May 8, 2014 · Tissue factor pathway inhibitor in endothelial cells colocalizes with glycolipid microdomains/caveolae. Regulatory mechanism(s) of the anticoagulant properties of the endothelium. Arterioscler Thromb Vasc Biol

Low levels of tissue factor pathway inhibitor (TFPI) increase the risk of venous thrombosis. Blood. 2003;101(11):4387–4392. doi: 10.1182/blood-2002-10-3188. [ DOI ] [ PubMed ] [ Google Scholar ]

Mar 30, 2025 · TFPI (Tissue Factor Pathway Inhibitor) is a Protein Coding gene. Diseases associated with TFPI include Thrombosis and Hemophilia . Among its related pathways are Diseases of hemostasis and Collagen chain trimerization .

Nov 24, 2015 · TF pathway inhibitor (TFPI) is a multivalent, Kunitz-type, serine protease inhibitor that was originally recognized as a plasma component that inhibited TF–fVIIa in a manner that required fX and calcium ions. 8 – 10 Subsequent studies demonstrated its pathophysiological importance by showing that immunodepletion of TFPI in rabbit models ...

May 8, 2014 · Tissue factor pathway inhibitor is expressed by human monocyte-derived macrophages : relationship to tissue factor induction by cholesterol and oxidized LDL.