T follicular helper cell differentiation, function, and roles in ...
Oct 16, 2014 · Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma 6 (Bcl6) and other transcription factors. This article reviews understanding of Tfh …
Follicular B helper T cells - Wikipedia
The function of T FH cells. A subset of naive T cells in the T cell zone are activated by antigen and migrate to the follicles where they differentiate into T FH cells that interact with and …
T follicular helper cells | British Society for Immunology
T follicular helper cells (Tfh) are a specialized subset of CD4 + T cells that were first identified in the human tonsil. They play a critical role in protective immunity helping B cells produce …
T follicular helper cell biology: A decade of discovery and diseases
The primary function of Tfh cells is to provide protection from infectious diseases. Tfh cells facilitate Ab responses to viral, bacterial, parasite, and fungal infections . As one example, the …
Understanding the development and function of T follicular …
Apr 12, 2010 · In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation, the relationship of Tfh cells to other CD4 + T-cell lineages, …
The origins, function, and regulation of T follicular helper cells
In recent years, T follicular helper (Tfh) cells have emerged as the key cell type required for the formation of GCs and the generation of long-lived serological memory (Vinuesa et al., 2005b; …
The development and function of follicular helper T cells in …
Jun 4, 2012 · By mediating the differentiation of B cells into memory and plasma cells following exposure to T-dependent antigens, follicular helper T (Tfh) cells have emerged as a subset of …
Stepwise differentiation of follicular helper T cells reveals distinct ...
Nov 24, 2023 · Tfh cells provide costimulatory signals and cytokines to B cells, promoting class switch recombination, somatic hypermutation, and affinity maturation. These signals also …
T follicular helper cell differentiation, function, and roles in ...
Tfh cell differentiation is a multi-stage, multi-factorial process involving B cell lymphoma 6 (Bcl6) and other transcription factors. This article reviews understanding of Tfh cell biology, including …
Insights Into the Molecular Mechanisms of T Follicular Helper …
Aug 15, 2018 · The Role of Tfh Cells in Diseases. The main function of Tfh cells is to control clonal selection of GC B cells and support B cell immunoglobulin synthesis, isotype switching, …