IL2-inducible T-cell kinase (ITK), a member of the Tec family tyrosine kinases, is the predominant Tec kinase in T cells and natural killer (NK) cells mediating T cell receptor (TCR) and Fc receptor (Fc R) initiated signal transduction.

May 15, 2021 · SLP-76 binds the Tec-family tyrosine kinase, Itk, which phosphorylates SLP-76 Y173 and PLC-γ1 Y783. In this study, we identified TCR-inducible, Itk-mediated phosphorylation of Gads Y45 in a human T cell line and in mouse primary T cells.

ITK is a Tec family non-receptor tyrosine kinase that plays multiple roles downstream of the TCR signaling. During the TCR signaling, ITK forms a complex with the adaptor molecule Slp-76, and is involved in the phosphorylation of PLC-γ and intracellular Ca 2+ mobilization.

ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell development as well as Th2, Th9 and Th17 responses thereby controlling the expression of pro-inflammatory cytokines.

Interleukin (IL)-2-inducible T cell kinase (ITK), a TEC-family kinase, is essential for T cell receptor (TCR) signaling. ITK functions as a tuning dial to translate variations in TCR signal strength into differential programs of gene expression.

Jun 21, 2017 · Here we show that ITK, an important modulator of TCR signalling, is required for the TCR-induced development of Tr1 cells in various organs, and in the mucosal system during parasitic and viral...

ITK signaling downstream of the T-cell receptor (TCR) is critical for T-cell subset differentiation and function. Upon activation by TCR, ITK is critical for Ras activation, leading to downstream activation of MAPKs and upregulation of IRF4, which further enable Tr1 cell differentiation and suppressive function.

Apr 1, 2005 · TEC-family kinases have a central role in the propagation of the signal induced by engagement of the T-cell receptor (TCR). ITK (interleukin-2-inducible T-cell kinase) forms a complex with...

IL-2-inducible T cell kinase (ITK) is essential for proximal T cell receptor (TCR) signaling. Following TCR ligation, ITK is recruited to the cell membrane where it interacts with Linker for activation of T cells (LAT) and SH2-domain-containing leukocyte protein of 76 kDa (SLP76) ( Qi et al., 2006 ; Bunnell et al., 2000 ).

Jul 23, 2024 · These findings suggest potential strategies for fine-tuning TCR signal strength through ITK to control the balance of T H 17 and T reg cells. Immune function mediated by T helper (T H) cells is critical for the development of effective barriers to pathogens and environmental toxins.