Soluble pathogenic tau enters brain vascular endothelial cells and ...
Apr 25, 2023 · Here we show that soluble pathogenic tau accumulates in brain microvascular endothelial cells of P301S (PS19) mice modeling tauopathy and drives AD-like brain …
Tau P301S (Line PS19) | ALZFORUM
Aug 14, 2014 · PS19 transgenic mice express mutant human microtubule-associated protein tau, MAPT, driven by the mouse prion protein (Prnp) promoter. The transgene encodes the …
Microglia and extracellular vesicle‐mediated spread of Tau …
Jan 3, 2025 · PS19 mice develop cognitive impairment as determined by Y-maze, forced alternation, novel object recognition and fear conditioning, which are reversed in …
Depletion of microglia and inhibition of exosome synthesis halt …
Oct 5, 2015 · We cross-examined the effect of microglial depletion on tau propagation using PS19 mice at 3.5 months of age. PS19 mice were treated with PLX3397 chow for 4 weeks.
JCI - Aberrant AZIN2 and polyamine metabolism precipitates tau ...
We showed that sustained AZIN2 overexpression elicited a maladaptive PSR in mice with underlying tauopathy (MAPT P301S; PS19). AZIN2 also increased acetylpolyamines, …
Differential induction and spread of tau pathology in young PS19 …
Here, we describe the rapid and distinct cell type-specific spread of pathological tau following intracerebral injections of CBD or AD brain extracts enriched in pathological tau (designated …
The Interplay between GSK3β and Tau Ser262 Phosphorylation …
Oct 1, 2022 · The level of tau phosphorylation at both sites, Ser199 and Thr231, was higher for both six- and 11-month samples of PS19 brain as compared to their healthy (WT) …
Evolutionarily conserved regulators of tau identify targets for new ...
Mar 15, 2023 · Injected PS19 mice and WT littermates were fed with a doxycycline (DOX)-containing diet to prevent shRNA expression until 2 months post-injection. At 2 months, mice …
Behavioural Functions and Cerebral Blood Flow in a P301S
Sep 8, 2021 · PS19 mice displayed hyperactivity and reduced anxiety levels with age, early and persistent spatial working memory deficits and reduced resting neocortical CBF. …
Tau pathology in P301S PS19 mice alters peripheral and cerebral ...
Dec 25, 2023 · This bidirectional relationship is well described in mouse models of Aβ overexpression; however, this relationship is relatively unexplored in mouse models of …