Transcriptional regulation of SYK through unique silencing of the SYK gene determines its basophil-specific expression patterns. Basophils (CD34B) were derived from cultures of CD34+ progenitor cells by two methods (G1 or G3).

Most are dependent on SYK expression and activity for survival as both siRNAs directed against SYK mRNA and the SYK inhibitor R406 induce apoptosis in these cells. In acute myeloid leukemia (AML), integrins can function upstream of SYK …

Dec 1, 2021 · Our studies based on chronic CCL4, bile duct ligation, and subacute TAA mouse models show that SYK in monocyte-derived macrophages (MoMFs) is fully dependent on phosphorylation of Erk to...

Syk protein and mRNA levels, across cell types, were relatively concordant. Syk mRNA in basophils showed a half-life of 3.5 h, which was greater than that of interleukin-4 or Fc epsilon receptor I-α mRNA (∼2 h), but somewhat shorter than Fc epsilon receptor I-β mRNA (8 h).

Spleen tyrosine kinase (SYK) plays a critical role in immune cell signaling pathways and has been reported as a novel biomarker for human hepatocellular carcinoma (HCC). We sought to investigate the mechanism by which SYK promotes liver fibrosis and to evaluate SYK as a therapeutic target for liver fibrosis.

Spleen tyrosine kinase (SYK) can behave as an oncogene or a tumor suppressor, depending on the cell and tissue type. As pharmacological SYK inhibitors are currently evaluated in clinical trials, it is important to gain more information on the …

Jan 1, 2025 · Spleen tyrosine kinase (SYK) exhibits diverse biological activities and participates in complex signaling pathways. SYK has vital roles in cancer, autoimmune diseases and other disorders. An overview of the development of SYK inhibitors hints at routes for future drug discovery efforts.

Dec 1, 2023 · In the present study, in CgSyk-RNAi oysters, the mRNA expressions of CgLC3, CgP62, CgBeclin-1 and CgATG5 decreased significantly after V. splendidus stimulation, suggesting that CgSyk might regulate the haemocyte autophagy process to defending against bacterial invasion.

Syk mRNA expression was found to be 5-30-fold lower than other cell types (CD34-derived basophils, peripheral blood eosinophils, and plasmacytoid dendritic cells). Syk protein and mRNA levels, across cell types, were relatively concordant.

May 15, 2023 · Herein, we found that SYK regulates the plasticity of cells in an epithelial state and is associated with their sensitivity to c-Metis both in vitro and in vivo in PDX models with c-Met...