A stem-loop occurs when two regions of the same nucleic acid strand, usually complementary in nucleotide sequence, base-pair to form a double helix that ends in a loop of unpaired nucleotides. Stem-loops are most commonly found in RNA, and are a key building block of many RNA secondary structures .

May 15, 2024 · What is a stem-loop (hairpin loop)? A Stem-loop can be defined as a hairpin-like pattern formed because of the intramolecular base pairing of the nucleotide sequence (especially in palindromic sequence) within the same molecule.

Mar 17, 2025 · Explore the formation, stability, and functional significance of stem-loop structures in nucleic acids, including their role in gene regulation and molecular processes. Certain nucleic acid sequences fold back on themselves, forming a distinctive stem-loop structure.

Aug 28, 2012 · The stem–loop structures, also called hairpins, play an important role in the tertiary folding of RNA molecules. They also serve as critical sites for the interaction with other nucleic acids and proteins.

Here, I review new diagnostic approaches based on the formation of stem-loop DNA oligonucleotides: molecular beacon methodology, suppression PCR approaches and the use of hairpin probes in DNA microarrays. The advantages of these techniques over existing ones for sequence-specific DNA detection, amplification and manipulation are discussed.

The structure is also known as a stem-loop structure. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when read in opposite directions, base-pair to form a double helix that ends in an unpaired loop.

Here we present a systematic analysis of SLS distribution in prokaryotic genomes. Sequences able to fold into stem-loop structures featuring relatively large (12 or more bp) stems have been searched and analyzed in 40 wholly-sequenced bacterial chromosomes.

RNA sequence analysis shows that base stacking and base pairing stabilize the stem–loops that kinetically trap the long-lived intermediates observed in the FDC. Stem–loops formation appears as a general mechanism to explain a wide range of behaviors observed in RNA folding.

May 15, 2023 · Stem-loops or hairpin loops are essential structural elements found in nucleic acids, specifically in RNA molecules. They are formed by base pairing between complementary nucleotides within the same strand, leading to the formation of …

A stem-loop structure is a secondary structure formed when single-stranded RNA or DNA folds back on itself, creating a double-stranded stem with an unpaired loop. These structures play critical roles in gene regulation and expression.