Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene. [5] [6]

The SMARCA2 gene provides instructions for making one piece (subunit) of a group of similar protein complexes known as SWI/SNF complexes. These complexes regulate gene activity (expression) by a process known as chromatin remodeling.

Mar 30, 2025 · Complete information for SMARCA2 gene (Protein Coding), SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2, including: function, proteins, disorders, pathways, orthologs, and expression.

Nov 10, 2022 · Selective SMARCA2 degradation is achieved in the absence of selective SMARCA2/4 PROTAC binding and translates to potent in vitro growth inhibition and in vivo efficacy in SMARCA4 mutant...

Jan 31, 2023 · Two new studies exploring PROTAC-mediated degradation of SMARCA2 for cancer therapy solve an apparently intractable selectivity challenge with SMARCA4 by utilising the requirement for a...

Mar 15, 2025 · SMARCA2 is an ATPase that regulates chromatin structure via ATP pathways, controlling cell division and differentiation. SMARCA2's bromodomain and ATPase domain, crucial for chromatin remodeling and cell regulation, are therapeutic targets in cancer treatment.

SMARCA2 has been identified as a key synthetic lethal target in SMARCA4-deficient cancers, yet the mechanism underlying the synthetic lethal relationship is unclear.

SMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma. Two cases of Nicolaides-Baraitser syndrome, one with a novel SMARCA2 variant.

Jul 31, 2023 · SMARCA2 is an attractive synthetic lethality target for human cancers with SMARCA4 deficiency. Herein, we report the design, synthesis, and biological evaluation of selective SMARCA2 protein degraders developed using the proteolysis targeting chimera (PROTAC) technology.

Sep 19, 2024 · Go to complete Gene record for SMARCA2; Go to Variation Viewer for SMARCA2 variants; Summary. The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila.