Mar 30, 2025 · SLC4A4 (Solute Carrier Family 4 Member 4) is a Protein Coding gene. Diseases associated with SLC4A4 include Proximal Renal Tubular Acidosis-Ocular Anomaly Syndrome and Renal Tubular Acidosis. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Disorders of transmembrane transporters.

Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a membrane transport protein that in humans is encoded by the SLC4A4 gene. [5][6][7] Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells.

Dec 15, 2022 · In PDAC-bearing mice, genetic or pharmacological SLC4A4 targeting improves T cell-mediated immune response and breaches macrophage-mediated immunosuppression, thus inhibiting tumor growth and...

Human mutations of NBCe1 (SLC4A4) are causative of early onset bilateral glaucoma and bilateral cataracts. This ocular neuropathy is associated with elevated intraocular pressure (IOP), while cataracts are related to an undetermined lens issue.

SLC4A4 is a novel driver of enzalutamide resistance in prostate cancer. Distal renal tubular acidosis, autoimmune thyroiditis, enamel hypomaturation, and tooth agenesis caused by homozygosity of a novel double-nucleotide substitution in SLC4A4.

Mar 2, 2018 · Na + -coupled acid–base transporters play essential roles in human biology. Their dysfunction has been linked to cancer, heart, and brain disease. High-resolution structures of mammalian...

We show that astrocytic Slc4a4 is required for normal astrocyte morphological complexity and BBB function. Multi-omics analyses identified increased astrocytic secretion of CCL2 coupled with dysregulated arginine-NO metabolism after Slc4a4 deletion.

Aug 10, 2024 · We performed an analysis of GEO databases and identified SLC4A4 as a major contributor to enza resistance. Enz-treatment activates SLC4A4 and mediates P53 lactylation via the NF-κB/STAT3/SLC4A4 axis, followed by drug resistance.

Oct 25, 2024 · Currently, the role of SLC4A4 in lung adenocarcinoma (LUAD) immunotherapy and prognosis was not entirely clear. Methods: We analyzed SLC4A4 expression in LUAD tissues and cell lines using quantitative reverse transcription-polymerase chain reaction, Western blotting, and immunohistochemistry.

Jan 4, 2025 · Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Inhibition of the sodium-dependent HCO3(-) transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype.