Zinc transporter SLC39A7 (ZIP7), also known as solute carrier family 39 member 7, is a transmembrane protein that in humans is encoded by the SLC39A7 gene. [5] [6] [7] [8] [9] [10] [11] It belongs to the ZIP family, which consists of 14 …

Mar 30, 2025 · SLC39A7 (Solute Carrier Family 39 Member 7) is a Protein Coding gene. Diseases associated with SLC39A7 include Agammaglobulinemia 9, Autosomal Recessive and Autosomal Agammaglobulinemia. Among its related pathways are Metal ion SLC transporters and Transport of inorganic cations/anions and amino acids/oligopeptides.

SLC39A7, regulated by miR-139-5p, induces cell proliferation, migration and inhibits apoptosis in gastric cancer via Akt/mTOR signaling pathway. Zinc transporter SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis.

Sep 20, 2018 · Orthogonal, solute carrier (SLC)-focused CRISPR/ Cas9 -based genetic screens revealed the exquisite specificity of SLC39A7, among ~400 SLC genes, for TNFR1-mediated and FAS-mediated but not...

SLC39A7 is phosphorylated by protein kinase casein CK2, associated with cell proliferation, migration, apoptosis, and mitosis 12, 13. Moreover, SLC39A7 has been reported to play a significant role in several cancers, such as cervical cancer, …

Sep 28, 2021 · Our findings identify upregulation of ZIP7 leading to suppression of mitophagy as a critical feature of myocardial reperfusion injury. A timely suppression of cardiac ZIP7 upregulation or inactivation of ZIP7 is essential for the treatment of reperfusion injury. Keywords: Mitochondrial Zn2+; Mitophagy; ROS; Reperfusion injury; ZIP7. © 2021.

Feb 8, 2025 · The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy. we have clarified the functional differences between ZIP7 and ZIP13 and show that their different regulation of cellular zinc homeostasis is critical for dermal development and homeostasis.

Jan 5, 2022 · Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and the intracellular storage compartments (summary by Taylor et al., 2004).

Synonym (s): ZRT/IRT-like protein 7, zinc transporter 7, ZIP7, RING5, KE4, D6S2244E, H2-KE4. Previous symbol (s) and name (s): HKE4, HLA class II region expressed gene KE4, solute carrier family 39 (zinc transporter), member 7. Type: gene with protein product. Chromosomal location: 6p21.32. OMIM: 601416. HGNC: 4927. UniProtKB: Q92504.

As shown in Figure 3D, siR-SLC39A7 significantly inhibited the number and size of cell colony compared with the control in MCF7 and MDA-MB-468 cells. These results suggested that SLC39A7 is a key gene for survival of BC cells. Figure 3. SLC39A7 played a vital role in cell survival of breast cancer.