Mar 30, 2025 · SLC25A1 (Solute Carrier Family 25 Member 1) is a Protein Coding gene. Diseases associated with SLC25A1 include Combined D-2- And L-2-Hydroxyglutaric Aciduria and Myasthenic Syndrome, Congenital, 23, Presynaptic. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and glycolysis (BioCyc).

Tricarboxylate transport protein, mitochondrial, also known as tricarboxylate carrier protein and citrate transport protein (CTP), is a protein that in humans is encoded by the SLC25A1 gene. [5] [6] [7] [8] SLC25A1 belongs to the mitochondrial carrier gene family SLC25.

The mitochondrial citrate carrier SLC25A1, also known as citrate transporter protein (CTP) or citrate/isocitrate carrier (CIC), is a mitochondrial membrane transporter encoded in the nucleus by the SLC25A1 gene located on chromosome 22q11.2.

Apr 12, 2018 · We demonstrate that SLC25A1 plays a key role in maintaining the mitochondrial pool of citrate and redox balance in CSCs, whereas its inhibition leads to reactive oxygen species build-up thereby...

Here, we use a targeted CRISPR-Cas9 screen of the SLC superfamily to identify SLC25A1 as a critical ferroptosis regulator in human cancer cells. SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY).

Oct 31, 2024 · Here, we describe a new mechanistic link between mitochondria and cardiac morphogenesis, uncovered by studying mitochondrial citrate carrier (SLC25A1) knockout mice.

Mar 16, 2025 · Title: The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. High expression of mitochondrial citrate transporter was associated with invasion and advanced tumor stage across many human cancers.

Nov 27, 2021 · Knockdown of SLC25A1 significantly inhibited the growth of CRC cells by suppressing the progression of the G1/S cell cycle and inducing cell apoptosis both in vitro and in vivo, whereas SLC25A1...

SLC25a1: citrate (tricarboxylate) carrier. Palmieri, Klingenberg and co-workers [62–64] first purified and reconstituted the CIC of the inner mitochondrial membrane. It was subsequently cloned by Kaplan et al. , which confirmed its identity as a SLC25 member.

Jan 22, 2021 · The mitochondrial citrate carrier SLC25A1, also known as citrate transporter protein (CTP) or citrate/isocitrate carrier (CIC), is a mitochondrial membrane transporter encoded in the nucleus by the SLC25A1 gene located on chromosome 22q11.2.