SET-PP2A complex as a new therapeutic target in KMT2A (MLL
Oct 27, 2023 · In this study we uncover the essential role and underlying mechanisms of SET, the endogenous inhibitor of Ser/Thr phosphatase PP2A, in KMT2A -R-leukemia.
A new regulatory mechanism of protein phosphatase 2A activity via SET ...
Jan 8, 2020 · We provide evidence that p38β potentiates SET-mediated PP2A inactivation by two mechanisms: facilitating SET cytoplasmic translocation through CK2 phosphorylation, and directly binding to and...
SET/PP2A signaling regulates macrophage positioning in hypoxic …
Oct 12, 2022 · We demonstrate that in response to a hypoxic environmental cue, SET translocates to the cytoplasm through the protein kinase C (PKC)-casein kinase 2α (CK2α) signaling axis and regulates...
PP2A complex disruptor SET prompts widespread ... - Science
Jan 26, 2024 · Through blocking PP2A activity, SET assisted CDK9 to maintain Pol II CTD phosphorylation and activated mRNA transcription. Our findings position SET as a key factor that modulates chromatin PP2A activity, promoting the oncogenic transcription in the …
The interaction of SET and protein phosphatase 2A as target
Disruption of the interaction between SET and PP2A to rescue the activity of PP2A may represent a new therapeutic strategy and opportunity for cancer treatment. This review brings up-to-date advances on the interactions between SET and PP2A and their biological consequences.
Targeting PP2A in cancer: Combination therapies - PMC
In addition to the core PP2A protein subunits, endogenous regulatory proteins for PP2A (e.g. CIP2A, SET, PME-1) provide further points of pharmacologic targeting to modulate PP2A function. PP2A is functionally impaired in cancer through inactivating mutations, suppression of individual subunits and up-regulation of endogenous regulators [ 15 ...
The interaction of SET and protein phosphatase 2A as target …
Aug 1, 2021 · This review brings up-to-date advances on the interactions between SET and PP2A and their biological consequences. Moreover, we review reported inhibitors of SET-PP2A interaction under investigation as therapeutic opportunities for the treatment of cancers.
SET-PP2A complex as a new therapeutic target in KMT2A (MLL
Oct 27, 2023 · In this study we uncover the essential role and underlying mechanisms of SET, the endogenous inhibitor of Ser/Thr phosphatase PP2A, in KMT2A-R-leukemia.
SET-PP2A complex as a new therapeutic target in KMT2A (MLL) …
In this study we uncover the essential role and underlying mechanisms of SET, the endogenous inhibitor of Ser/Thr phosphatase PP2A, in KMT2A -R-leukemia.
Targeting SET/I 2 PP2A Oncoprotein Functions as a Multi-pathway ...
COG112 treatment releases the SET-mediated inhibition of the tumor suppressor PP2A, as well as the metastasis suppressor nm23-H1. These results establish SET as a novel molecular target, and that the inhibition of SET may have beneficial effects in cancer chemotherapy. Keywords: SET/I 2 PP2A, PP2A, Akt, nm23-H1, Rac1.