Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. [5] [6] [7] Also known as the ubiquitin-binding protein p62, [8] it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy.

Mar 30, 2025 · SQSTM1 (Sequestosome 1) is a Protein Coding gene. Diseases associated with SQSTM1 include Paget Disease Of Bone 3 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3. Among its related pathways are p75 NTR receptor-mediated signalling and Selective autophagy.

Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the transportation, degradation and destruction of various proteins that cooperates with components of autophagy and the ubiquitin-proteasome degradation pathway.

Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the transportation, degradation and destruction of various proteins that cooperates with components of autophagy and the ubiquitin‑proteasome degradation pathway.

Apr 7, 2025 · This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals.

The protein Sequestosome 1 (p62/SQSTM1) is a classical selective autophagy receptor, but it also has roles in the ubiquitin-proteasome system, cellular metabolism, signaling, and apoptosis. p62 is best known for its role in clearing protein aggregates via aggrephagy, but it has recently emerged as a receptor for other forms of selective ...

Jan 1, 2007 · Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor internalization, and protein turnover. Herein we review recent advances in the field.

Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide. p62 is recruited to Salmonella typhimurium targeted by autophagy. Recruitment of p62 is associated with ubiquitinated proteins localized to the bacteria and reveals a …

The SQSTM1 gene encodes a scaffolding protein that regulates a variety of biologic processes, including NFKB1 (164011) signaling, apoptosis, transcription regulation, and ubiquitin-mediated autophagy (review by Rea et al., 2014).

Jun 18, 2024 · In this scenario, the autophagic cargo sequestome-1 (SQSTM1/p62) emerges as a target of DOPAL-dependent oligomerization and accumulation in cytosolic clusters. Although DOPAL-induced oxidative...