Uteroglobin, or blastokinin, also known as secretoglobin family 1A member 1 (SCGB1A1), is a protein that in humans is encoded by the SCGB1A1 gene. [5] SCGB1A1 is the founding member of the secretoglobin family of small, secreted, disulfide …

Mar 30, 2025 · SCGB1A1 (Secretoglobin Family 1A Member 1) is a Protein Coding gene. Diseases associated with SCGB1A1 include Asthma and Silicosis . Among its related pathways are Prostaglandin synthesis and regulation and FOXA1 transcription factor network .

Jan 27, 2023 · Club cell secretory protein (CCSP), also known as secretoglobin 1A1 (gene name SCGB1A1 ), is one of the most abundant proteins in the lung, primarily produced by club cells of the distal airway epithelium.

Mar 12, 2024 · Rare bronchioalveolar stem cells (BASCs), co-expressing Scgb1a1 and Sftpc, can be found in the bronchioalveolar duct junction. The alveoli are lined by cuboid alveolar type 2 cells (AT2)...

Mar 2, 2025 · In vitro assays were conducted to evaluate the role of secretoglobin family 1a member 1 (SCGB1A1) in macrophage activation and lymphocyte proliferation. Carbon clearance assays revealed a significant reduction in splenic phagocytic activity in the smoke-exposed group.

Secretoglobin family 1A member 1 (SCGB1A1) alternatively known as club cell protein 16 is a protective pneumo-protein. Decreased serum levels of SCGB1A1 have been associated with tobacco smoke induced chronic obstructive pulmonary disease (TS-COPD).

Oct 1, 2020 · Alveolar macrophage (AM) is a mononuclear phagocyte key to the defense against respiratory infections. To understand AM's role in airway disease development, we examined the influence of Secretoglobin family 1a member 1 (SCGB1A1), a pulmonary surfactant protein, on AM development and function.

low levels of epithelial SCGB1A1 in asthma are caused by reduced FOXA2 expression. CC16 is a homodimeric pneumoprotein encoded by the SCGB1A1 gene and, although produced predominantly by club cells and nonciliated epithelial cells in the distal airways, it is easily detectable in the circulation.

Feb 8, 2025 · Scgb1a1-expressing cells, most likely Clara cells, are a major cell type that gives rise to alveolar type I and II cells during the regeneration of alveolar epithelia in response to severe pulmonary damage in mice.

Secretoglobins (SCGBs) are cytokine-like small molecular weight secreted proteins with largely unknown biological functions. Three SCGB proteins, SCGB1A1, SCGB3A1, and SCGB3A2, are predominantly expressed in lung airways.